Raltegravir

Raltegravir Mustafa Khan Mahwish Khan Ted French Alex Liu BMED 3600 Final Project conceptualise Use and Mechanism On October 2007, the U.S victual and Drug Administration (FDA) approved the uptake of raltegravir (Isentress) for the treatment of homophile(prenominal) immunodeficiency virus-1 (human immunodeficiency virus-1). It received further acclamation on December 2011 for delectation in pediatric patients ages 2-18. Raltegravir contains raltegravir potassium, a HIV-1 integrase strand transfer inhibitor. It is think to be used in combination with both some other antiretroviral drugs, one peptidase inhibitor and one non-nucleoside reverse transcriptase inhibitor. The chemical substance fall upon for raltegravir potassium is: N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl) carbonyl] amino]ethyl]-6-oxo-4-pyrimidinecarboxamide monopotassium salt. HIV-1 success encompassingy replicates in the human proboscis by utilizing three enzymes: reverse transcriptase, integrase, and protease. Its life sentence cycle initiates with presentation into legion immune cells that express excavate CD4. Infection is initiated by the discriminating binding of CD4 receptors with the viral out(prenominal) envelope glycoprotein (gp120). This induces conformational changes on the HIV tissue layer that ply for the recognition of chemokine receptors on the bearing ara cell.

The interaction among chemokine receptors and the HIV membrane at last leads to membrane fusion. After opening into the host cell, the HIV-1 reverse transcriptase converts the hotshot stranded viral RNA into double-stranded desoxyribonucleic acid (cDNA). At this point, integrase binds to the cDNA, creating a pre-integration complex, and transports it into the nucleus. The integration of the viral cDNA into the host genome involves two steps, two of which are catalyzed by the integrase enzyme. First, two nucleotides from the 3 give notice are excised from the nascent HIV-1 DNA. This is followed by the covalent insertion of viral DNA into the host DNA. The integrase-mediated strand...If you sine qua non to get a full essay, smart set it on our website: Ordercustompaper.com

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